| abstract |
The present invention relates to substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanone or salt thereof of general formula (I), preferably a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described herein. The present invention furthermore relates to the preparation of said compounds, to pharmaceutical compositions comprising compounds of general formula (I), and to the use of said compounds for the treatment of various pathologies, such as those involving positive symptoms of schizophrenia and negative symptoms, and cognitive impairment associated with schizophrenia, Alzheimer's disease, and other neurological and psychiatric disorders. The compounds of the invention exhibit glycine transporter-1 (GIyT 1 ) inhibitory properties. |