| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db9efde660b78f98b102046e09d07ab7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 |
| filingDate |
2016-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_838a2abcb9705fc5c20b7b28c9b0cb78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_789637482348be1e9e5fc6f8265b04a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74774848ec536b5ff68aaed9ea1845c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2c2f1970bf163b3840e04ccde099f3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d232d21eed68034c814c146053808a5 |
| publicationDate |
2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-105837493-A |
| titleOfInvention |
The synthetic method of nintedanib and its intermediate |
| abstract |
The invention discloses a synthesis method of nintedanib and an intermediate thereof. The synthesis method comprises: reacting a compound of formula (II) with a compound of formula (I) under acidic conditions to generate a compound of formula (III); Remove the tert-butyl carbonate group of the compound of formula (Ⅲ), and react with base again to generate the compound of formula (Ⅴ); Basepiperazine reaction to obtain nintedanib. The invention provides a new synthesis method of nintedanib with mild reaction conditions, and also provides an intermediate for synthesizing nintedanib. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10961203-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111662223-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111662223-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11261158-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106543069-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018165865-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020508979-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021176899-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7306697-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110072849-A |
| priorityDate |
2016-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |