| abstract |
The present invention relates to tetrahydro-tetrazolo[1,5-a]pyrazine compounds of formula (I), wherein R 1 represents -R 3 , -CH 2 -R 3 or -(C=O)-R 3 ; R 2 represents Ar 2 , Hetar 2 or C 3-7 -cycloalkyl; and R 3 represents Ar 3 , Hetar 3 or C 3-7 -cycloalkyl. These compounds are useful for inhibiting retinoic acid-related orphan receptor gamma (RORγ, ROR‑γ) and for preventing and/or treating medical diseases affected by RORγ activity, such as rheumatoid arthritis, multiple sclerosis, psoriasis, ulcerative colon inflammation, asthma, autoimmune hepatitis or type I and type II diabetes. |