| abstract |
The present invention provides a compound of formula (I) or a salt thereof: wherein R 1 , X and R 3 are as defined in the description, which is used for the treatment of diseases mediated by KMO, such as acute pancreatitis, chronic kidney disease, and systemic inflammatory response Other conditions related to SIRS, Huntington's disease, Alzheimer's disease, spinocerebellar ataxia, Parkinson's disease, AIDS-dementia complex, amyotrophic lateral sclerosis (ALS), depression, psychosis Schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, major surgery, ischemic enteropathy, severe acute liver disease, severe acute Hepatic encephalopathy or acute renal failure. |