| abstract |
The present invention relates to a kind of CTL epitope polypeptide of human epidermal growth factor acceptor, which has amino acid sequence shown in SEQ ID NO.2；Or the polypeptide replaces on the basis of have the amino acid sequence shown in SEQ ID NO.2, the derived sequence of missing, displacement, insertion and/or addition one to several amino acid.The present invention also provides a kind of vaccines, CTL epitope polypeptide and adjuvant including human epidermal growth factor acceptor, and the adjuvant is gp96 albumen.Have by the cooperation of adjuvant and the CTL epitope polypeptide of human epidermal growth factor acceptor, have many advantages, such as to improve immunity, significantly improves treatment tumor effect. |