| abstract |
The invention belongs to the field of medicine and chemical industry, and specifically relates to the synthesis process of oxiracetam, which uses ethyl acetoacetate and glycine as raw materials, and ethyl acetoacetate undergoes a halogenation reaction to form 4-halogenated ethyl acetoacetate, which is formed with glycine Glycine ester is cyclized to generate 2,4-dioxo-1-pyrrolidine acetate, which is hydrolyzed and ammonolyzed to obtain 4-hydroxy-2-oxo-1-pyrrolidineacetamide. The raw materials involved in the invention are simple and easy to obtain, the synthesis process is simple, and the invention has good industrial value. |