http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105816883-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105816883-B |
| titleOfInvention | A kind of probiotics folate-targeted carrier and preparation method thereof loading anticancer drug curcumin |
| abstract | The invention discloses a kind of probiotics targeting vectors and preparation method thereof for loading anticancer drug curcumin.Curcumin is connected with the spore surface of bacillus coagulans by esterification first, synthesis obtains curcumin-probiotics carrier (CUR-Spore)ï¼›Upper folic acid is connected by esterification again, the probiotics folate-targeted carrier (CUR-Spore-FA) of load curcumin is successfully prepared.The target medicine carrier can be applied to the treatment of colon cancer well, have targeting, and can reduce the toxic side effect of drug.Meanwhile there are also protective effects for curcumin for bacillus coagulans in the carrier medicament, can be resistant to gastric acid and be smoothly through stomach, are colonized in intestines and sprout release curcumin in enteron aisle to treat colon cancer.The present invention is to improve the utilization rate of curcumin, establishes the targeted delivery system of anticancer drug and the treatment applied to colon cancer is laid a solid foundation, and provides a kind of new mode for the treatment of colon cancer. |
| priorityDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 173.