| abstract |
A series of substituted pyrazolecarboxylic simultaneously [1,5 a] pyridine derivate, as effective conditioning agent of human TNF alpha activity, correspondingly valuably treats and/or prevents various people's disease illness, including autoimmunity and inflammation sexual dysfunction；Neurological disorders and neurodegeneration obstacle；Pain and nociception sexual dysfunction；Cardiovascular disorder；Dysbolism；Eye disorder；With oncology obstacle. |