| abstract |
A series of tricyclic benzimidazole derivatives, especially dihydro 1H imidazo[1,2a]benzimidazole, dihydro 1H pyrrolo[1,2a]benzimidazole, dihydro 1H pyrazino[1,2a ]benzimidazole, dihydro 1H[1,4] Azizo[4,3a]benzimidazoles and dihydrothiazolo[3,4a]benzimidazoles and their analogues are potent modulators of human TNFα activity and are therefore useful in the treatment and/or prevention of various human diseases Of benefit, the human diseases include autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; |