| abstract |
A series of substituted fused tricyclic imidazole derivatives, especially dihydro-1H-pyrano[4',3':4,5]imidazo[1,2-a]pyridine, 1,2,3, 4‑tetrahydroimidazo[1,2‑a:5,4‑c']dipyridine, dihydro‑1H‑pyrano[3',4':4,5]imidazo[1,2‑a ]pyridine and tetrahydro-6H-cyclohepta[4,5]imidazo[1,2-a]pyridine, and their analogues, they are effective regulators of human TNFα activity, and are therefore useful in the treatment and treatment of various human diseases There is/or benefit in the prevention of human diseases including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. |