http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105801573-B
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
filingDate | 2016-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2017-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-105801573-B |
titleOfInvention | It is a kind of to synthesize jamaicin category and in ebony wood category natural products 66 and the method for ring structure |
abstract | Jamaicin category and in ebony wood category natural products 66 and the method for ring structure are synthesized the invention discloses a kind of, methods described is to make the conjugated enynes ester with Formula II structure that the series connection cyclization of intramolecular occur in a solvent, so as to which 66 shown in Formulas I and ring structure is made, specific reaction equation is: In formula:R 1 And R 2 It is respectively and independently selected from hydrogen, alkyl, cycloalkyl, aryl or heterocyclic radical;Or, R 1 And R 2 Saturation or undersaturated carbocyclic ring or heterocycle are formed together;R 3 And R 4 It is respectively and independently selected from hydrogen, alkyl, cycloalkyl, aryl or heterocyclic radical;Or, R 3 And R 4 Saturation or undersaturated carbocyclic ring or heterocycle are formed together;R is selected from C 1 ~C 4 Alkyl;P is amino protecting group.The method of the invention has simple to operate, and safety and environmental protection, production cost is low, high income, the advantages of being adapted to large-scale production, has important value to promoting such compound in the extensive use of field of medicaments. |
priorityDate | 2016-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.