http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105801466-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-38 |
| filingDate | 2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105801466-B |
| titleOfInvention | A kind of β-alkoxy-β-quaternary carbon center-alpha-amino acid derivatives and its synthetic method and application |
| abstract | The invention discloses a kind of new β as shown in formula (4)-alkoxy-β-quaternary carbon center-alpha-amino acid derivatives, using diazonium compound, imines and aryl methanol as raw material, with Molecular sieve is water absorbing agent, using chiral BINOL phosphoric acid and rhodium acetate as co-catalyst, using organic solvent as solvent, obtains the β-alkoxy-β-quaternary carbon center-alpha-amino acid derivatives by single step reaction.Synthetic method of the present invention has atom economy, highly selective, high yield advantage, and reaction condition is mild, safety easy to operate.The invention also discloses the β-alkoxy-β-quaternary carbon center-alpha-amino acid derivatives to inhibit the application in Protein-tyrosine-phosphatase PTP1B activity, potential activity molecule is provided to treat the screening of diabetes and obesity lead compound, is important chemical industry and medicine intermediate. |
| priorityDate | 2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 165.