abstract |
The present invention describes an alternative continuous downstream process for the preparation of 5?acetamido?N,N'?bis(2,3?dihydroxypropyl)?2,4,6?triiodoisophthalamide ("Compound A") method. Compound A is a key intermediate in the preparation of iodixanol and iohexol, two of the most important commercially available non-ionic x-ray contrast agents. |