http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105777711-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C63-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2016-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105777711-B |
| titleOfInvention | A kind of pharmaceutical co-crystals body and preparation method thereof of Lomefloxacin and 5-F- M-phthalic acids |
| abstract | The present invention relates to technical field of pharmaceutical co-crystal, relate in particular to the pharmaceutical co-crystals body and preparation method thereof of Lomefloxacin and 5 fluorine M-phthalic acids.By the ethanol/water or methanol/water solution of slow evaporation eutectic salts are formed with a variety of rate crystallizations.Because the reagent alcohol and water that eutectic synthesis uses are nontoxic, required consersion unit is simple, the method of making is simple and practicable, product stability is good, and reproducibility is good, and the eutectic being prepared has thermal stability good, the advantages that molar yield is high, be conducive to industrialized production, and the eutectiferous formation of the drug combination had not only remained the pharmacological properties of drug itself, but also possibility is provided for the physicochemical properties, raising drug effect and bioavilability of modified medicaments.The pharmaceutical co-crystals have preferable effect to dissolubility, the stability etc. that improve Lomefloxacin. |
| priorityDate | 2016-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.