http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105777634-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-18 |
| filingDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105777634-B |
| titleOfInvention | A kind of method for synthesizing the aryl ketone class compound of isoquinolin 1 |
| abstract | The invention discloses a kind of method for synthesizing the aryl ketone class compound of isoquinolin 1,10% Pd catalyst, 15 mL aprotic polar solvents are added in tube sealing, after 5 ~ 10min is stirred at room temperature, add 0.6mmol isoquinoline nitrogen oxides, 0.5mmol aromatic nitro alkene, 110 o 12 ~ 16 h are reacted under C, open or tube sealing reaction, TLC tracking reactions, after question response is complete, room temperature is cooled to, reactant is poured into 10 ~ 20mL water, and with the extraction of 20 ~ 30mL dichloromethane three times, finally use anhydrous Na 2 SO 4 Dry, filtering, removal of solvent under reduced pressure, purified through silica gel column chromatography, ethyl acetate/petroleum ether=1：10 ~ 20 be eluant, eluent, obtains product.The laboratory facilities that this method passes through simple and effective, the aryl ketone class compound of isoquinolin 1 is synthesized, it is the important as precursors of oxoaporphinoid, this method only need the simple Heck reactions of a step can cyclization, it is simple to operate, raw material is easy to get, reactions steps are few, and yield is high, has good application value, prospect is extensive, and is suitable for industrialization production. |
| priorityDate | 2016-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.