http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105777544-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-48 |
| filingDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105777544-B |
| titleOfInvention | A kind of preparation method of S- (+)-flurbiprofen axetil |
| abstract | The invention discloses a kind of preparation methods of S- (+)-flurbiprofen axetil, include the following steps：(1) in the presence of alkali and organic solvent, S- (+)-Flurbiprofen is made to be reacted with 1- substituted acetic acid ethyl esters, reaction temperature is 0-25 DEG C, and the reaction time is 3-15 hours；(2) by the extraction of the product of the reaction, washing, and grease is isolated；(3) grease is subjected to column chromatography purifying；(4) the method removing co-evaporated by solvent is organic molten residual, is then dried in vacuo to obtain target product.The present invention avoids inorganic base, is studied from the organic base high with organic solvent intersolubility, and suitable solvent burden ratio is selected, and ensure that the progress of reaction, common racemization and product decomposing phenomenon are not found in preparation process；For S- (+) prepared by the present invention-flurbiprofen axetil total recovery up to 80% or more, optical purity is more than 99%. |
| priorityDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.