| abstract |
The invention discloses a hydroxamic acid derivative and its preparation method and application. The structure of the hydroxamic acid derivative of the present invention is shown in formula I, wherein the definitions of R 1 , m, n, X and R 2 are as follows described in the specification and claims. The hydroxamic acid derivatives of the present invention can inhibit the activity of LpxC deacetylase, have antibacterial activity, especially can inhibit Gram-negative bacteria, and are especially suitable for the preparation of prophylaxis and/or treatment of gram-negative bacteria. Drugs for related diseases. |