| abstract |
The invention belongs to the field of material chemistry and biological medicine, and in particular relates to a preparation method and application of a metal sulfur-group compound multifunctional nano probe. The preparation method comprises the following steps: in the presence of a water-soluble sulfhydryl compound or a biocompatible molecule, enabling low-valence sulfur group anions to have stirred mixing reaction with metal cations in an aqueous solution; and then, centrifuging, carrying out ultrafiltration, modifying, dialyzing and purifying to obtain water-soluble metal sulfur-group compound nanoparticles which can be used for photoacoustic imaging, CT imaging, nuclear medical imaging and photothermal therapy. The preparation method is gentle, cheap, quick and efficient; and the obtained nano microparticles are small in size, can circulate for a relatively long time in vivo, and can be gathered in tumors by enhancing permeation and retention effects. |