| abstract |
The present invention provides a new compound that inhibits the interaction between Mdm2 (mouse double minute 2) protein and p53 protein and exhibits antitumor activity. The present invention provides disspiropyrrolidine derivatives represented by formula (1), which inhibit the interaction between Mdm2 protein and p53 protein, exhibit antitumor activity, and have various substituent groups. (R 1 , R 2 , R 3 and rings A and B in formula (1) are the same as defined in the description). |