| abstract |
The invention discloses a preparation method of a polyethylene glycol-b-aliphatic polycarbonate amphiphilic block polymer.The method comprises the steps that epoxide or epoxide and lactone and polyethylene glycol or polyethylene glycol with the single capped end are added into a polymerizing pot on the basis that the rate of charge is 10-10000, 1-10 MPa CO2 is introduced after sealing is performed, a reaction is performed for 2-72 h under the temperature of -50-100 DEG C, crude products are dissolved into chloroform, and then ethyl alcohol or petroleum ether is adopted for precipitation, separation and drying to obtain the polyethylene glycol-b-aliphatic polycarbonate amphiphilic block polymer.The obtained polyethylene glycol-b-aliphatic polycarbonate amphiphilic block polymer is an environment-friendly biodegradable macromolecule, can be assembled to nano particles in water, and can also be used as a drug control release nano-carrier. |