http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105732666-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6648e0352741f12c4d443077dd104b2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2009-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_537a7379403f0e55c5385e0abd889407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0981c686b9d7bdd1ac52252edf9749fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_874edb6aa6977842aeca16d849d1666f |
| publicationDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105732666-A |
| titleOfInvention | Asymmetric pyrrolobenzodiazepine*-dimers for the treatment of proliferative diseases |
| abstract | The present invention relates to asymmetric pyrrolobenzodiazepines for use in the treatment of proliferative diseases - dimers. Specifically, the present invention claims asymmetric pyrrolobenzodiazepines of formula (I) - a dimer (PBD-dimer), which is asymmetric at least due to the values represented by the variables R 12 and R 2 . Formula (I), wherein: R 2 is formula (II), wherein A is C 5-7 aryl group, X is selected from OH, SH, CO 2 H, COH, N=C=O, NHR N (wherein R N is selected from H and C 1-4 alkyl) and (OC 2 H 4 ) m OCH 3 , wherein m is 1-3, and: (i) Q 1 is a single bond, and Q 2 is selected from a single bond and -Z-(CH 2 ) n -, wherein Z is selected from single bond, O, S and NH, and n is 1-3; or (ii) Q 1 is -CH=CH-, and Q 2 is a single bond ; R 12 is a C 5-10 aryl group, which is optionally substituted by one or more groups selected from the group consisting of halogen, nitro, cyano, ether, C 1-7 alkyl, C 3- 7 heterocyclyl and dioxy-C 1-3 alkylene. Other variables are as defined in the claims. The compounds are useful in the treatment of proliferative diseases. |
| priorityDate | 2008-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.