http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105732619-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4e13141d402ceb885f368dfa042348 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af11075e49032e568c18526db16c2d7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab6e8f7884b38f592705e854f5b14f7e |
| publicationDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105732619-A |
| titleOfInvention | A kind of synthetic method of 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine compounds |
| abstract | The invention belongs to the technical field of pharmaceutical chemical synthesis and discloses a synthesis method of 5,6,7,8?tetrahydropyrido[2,3?d]pyrimidine compounds. The synthesis method is as follows: in the reactor, add compound 1 with the structure of formula (1), compound 2 with the structure of formula (2), a metal catalyst, a ligand and a solvent, then add alkali as a promotor, and feed inert gas , Stir the reaction at 40-150°C for 1-48 hours, cool to room temperature after the reaction, dilute the reaction solution, filter, and evaporate the solvent under reduced pressure to obtain a crude product, which is purified by column chromatography to obtain 5,6,7, 8? Tetrahydropyrido [2,3? d] pyrimidine compounds. The invention uses alcohol and nitrile as raw materials to synthesize 5,6,7,8?tetrahydropyrido[2,3?d]pyrimidine compounds in one step, and has the advantages of simple synthesis steps, safe operation of the synthesis method, non-toxic raw materials, low price and no harm to the skin. The advantage of good adaptability of functional groups. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109180661-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115028598-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110872291-A |
| priorityDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.