http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105732568-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-06 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-06 |
filingDate | 2016-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2018-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-105732568-B |
titleOfInvention | A kind of synthetic method of Atorvastatin calcium chiral intermediate |
abstract | The invention discloses a kind of synthetic methods of Atorvastatin calcium chiral intermediate, belong to the synthesis technical field of medicine intermediate.Technical scheme of the present invention main points areļ¼ .The process route not only avoids the use of dangerous, hypertoxic, the expensive drug such as butyl lithium in chemical synthesis, potassium cyanide and periodic acid, and it is effectively improved since the use of tetra isopropyl oxygen titanium and S xenol mixing chiral catalysts is worth to the ee of product, and alkene and nitro can be restored simultaneously in atmospheric conditions, the synthetic method raw material is cheap and easy to get, route is easy to operate, reproducible and yield is very high, is suitble to industrialized production. |
priorityDate | 2016-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 698.