| abstract |
The invention mainly relates to a purification method of recombinant sendai viruses, which is suitable for the large-scale preparation of recombinant sendai virus-vectored vaccines. The purification method is characterized by comprising the following steps: vacuum filtration, affinity chromatography, ultrafiltration, nuclease treatment and gel filtration chromatography. The purification method has the advantages that the operation is simple, the quality is stable, the yield is high, etc. |