| abstract |
The invention discloses a π-extended s-triazepine derivative and a synthesis method thereof. The structural formula of the derivative is Where R represents C 1 ~ C 10 alkyl, R 1 , R 2 , R 3 each independently represent H, C 1 ~ C 4 alkyl, C 1 ~ C 4 alkoxy, phenyl, C 1 ~ C 4 Any of the phenyl groups substituted with 1,5,9?triamino?2,3,6,7,10,11?hexaalkoxytriphenylene and salicylaldehyde or salicylaldehyde Derivatives are used as raw materials, and the Pictet-Spengler reaction is carried out under acid catalysis, and then the intramolecular nucleophilic substitution reaction is carried out under alkaline conditions to obtain π-extended s-triazepine derivatives in one pot. The reaction conditions are mild and the operation The method is convenient, and the product yield is high, and the yield of some products can reach more than 90%, which is a convenient method for synthesizing this type of compound. |