| abstract |
The invention discloses 2-substituted oxy-5-methylsulfonyl arylpiperazine amide analogs and a preparation method and application thereof. Specifically, the present invention relates to a 2-substituted oxy-5-methylsulfonyl arylpiperazinamide analog of the compound of formula (I) and its preparation method and application, wherein the substituents in the compound of formula (I) are such as as defined in the manual. The series of compounds have the activity of inhibiting glycine transporter-1 (GlyT1), and can be used to treat related diseases in the central nervous system and mental fields, such as schizophrenia (including positive symptoms, negative symptoms and cognitive symptoms), Alzheimer's disease , Parkinson's disease and other related psychiatric diseases, it has a wide range of applications in the prevention and treatment of central nervous system and psychiatric diseases, and is expected to be developed into a new generation of GlyT1 inhibitors. |