http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105712918-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c2119fbe39b66a0a9b862230c15c6d1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-08 |
| filingDate | 2016-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5734afb89917f70d9f980fc252e94460 |
| publicationDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105712918-A |
| titleOfInvention | A kind of synthetic method of pharmaceutical intermediate lactam compound |
| abstract | The present invention relates to a kind of synthetic method of the lactam compound shown in following formula (III), described method comprises: in solvent, in the presence of catalyst, oxidizing agent, alkali and additive, following formula (I) compound and following formula ( II) the compound reacts, and after the reaction is finished, it is post-treated to obtain the compound of formula (III), Wherein, Ar is unsubstituted or substituted phenyl, unsubstituted or substituted thienyl or unsubstituted or substituted naphthyl, and the substituent is C 1 -C 6 alkyl, C 1 -C 6 alkoxy or halogen; X is halogen. The method can obtain the target product with high yield through the comprehensive selection and synergy of catalyst, oxidant, base, additive and solvent, and has good application prospect and industrial production potential in the field of organic synthesis, especially the synthesis of pharmaceutical intermediates. |
| priorityDate | 2016-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 15.