http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105705483-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71b944100daf03103e6704d7474fd127 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 |
| filingDate | 2014-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad1726b310bdcf96a81a95823b618796 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd1b0b6b5487a9c3b488b3afad748a0b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26af1d3be53ce309af2169b415eb6006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8793e6319adb328d35dcb34993e823e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ae6ad06847e3e0eca7f084c34e2cd4d |
| publicationDate | 2016-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105705483-A |
| titleOfInvention | The preparation method of iopamidol |
| abstract | The invention discloses a preparation method of iopamidol of formula (II) and comprising the following steps: a) compound (I) (wherein X is OR 2 or R 3 , and wherein R 2 and R 3 are C 1 -C 6 linear or branched alkyl, C 3 -C 6 ring Alkyl, C aryl, optionally substituted by a group selected from the group consisting of methyl, ethyl, n - propyl, i-propyl, n-butyl, sec-butyl, tert-butyl and phenyl) and The acylating agent (S)-2-(acetyloxy)propionyl chloride is reacted in a reaction medium to obtain an acetyloxy derivative of compound (I); b) by adding water or a dilute alkaline solution, such as hydrogen Sodium oxide or potassium hydroxide is used to hydrolyze the intermediate of step a) with an aqueous solution at a pH of 0 to 7, and the hydroxyl group is freed from the boron-containing protecting group to obtain the N-(S)-2-(acetyl group of compound (II) oxy)propionyl derivatives; c) base hydrolysis to restore the (S)-2-(hydroxy)propionyl group and give iopamidol (II), optionally recovering the boron derivative from the solution obtained in step b) thing. The boron-containing protecting groups are versatile, efficient and recyclable. A one-pot synthesis without the isolation of intermediates is provided, resulting in reduced recovered and recycled solvents and significantly increased yields, representing significant advantages in terms of cost-effectiveness and environmental awareness of the overall process. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109293526-A |
| priorityDate | 2013-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 168.