| abstract |
In the present application, high affinity anti-GD 2 antibody agents are described, as well as various methods and reagents related thereto, including, for example, methods and reagents for the detection, prevention and/or therapeutic treatment of GD 2-associated diseases, in particular, neuroblastoma. The present invention provides antibody agents that bind to GD2 that are variants of the reference 3F8 antibody in that they contain one or more specific structural features not found in the reference 3F8 antibody and described herein. In some embodiments, the provided antibody agents are useful in medicine, e.g., for diagnosing and/or treating neuroblastoma. |