http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105693633-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-12 |
| filingDate | 2016-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105693633-B |
| titleOfInvention | The preparation method of the benzodiazepine -2- ketone of -1,5- containing fluoroalkyl |
| abstract | The present invention relates to a kind of preparation methods of 2 ketone containing 1,5 benzodiazepine of fluoroalkyl.This method is by fluorinated acyl acetic acid esters and substituted o-phenylenediamine by 1.0~1.5:1.0~1.2 molar ratio is dissolved in organic solvent, and the L proline of catalytic amount is added as catalyst, and return stirring is reacted to reaction, removes solvent, then through column chromatography for separation, obtain containing 1,5 benzodiazepine of fluoroalkyl, 2 ketone compounds.The advantages of preparation method of the present invention is：This method is environmentally friendly.And raw material is easy to get, and is catalysis with organic molecule, reaction condition is mild, and universality is strong, convenient post-treatment, and product yield is higher. |
| priorityDate | 2016-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.