| abstract |
The invention discloses a compound of formula I with higher protein kinase G (PKG) inhibitory activity and a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the new compound, and the new compound is effective in treating pain, Especially in the treatment of chronic pain applications. A preparation method and a new intermediate of the compound are also disclosed. Wherein R 1 and R 2 are the same or different, selected from halogen (eg, F or Cl), C 1 -C 6 alkoxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl and C The group consisting of 2 - C6 alkynyl groups; R3 is a terminal group selected from the group consisting of H, halogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl and heteroaryl; n is a repeating unit The number is an integer of 0-15. |