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filingDate 2016-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2019-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-105688288-B
titleOfInvention Compound oral restoration membrane material of collagen-based and preparation method thereof
abstract The invention discloses compound oral restoration membrane materials of collagen-based and preparation method thereof, this method comprises the following steps: being carried out first using oxidated carboxymethyl chitosan to Type I collagen cross-linking modified, and promote the self assembly of collagen using thermal drivers method simultaneously, then collagen-based material is successively carried out further to be crosslinked and is handled with pre-calcification, finally biomimetic mineralization is carried out in 1 ~ 10 times of SBF solution added with trace P AA solution, product is freeze-dried, sterilization treatment is to get the compound oral restoration membrane material of collagen-based.Self assembly and biomimetic mineralization of the membrane material by collagen, in the forming process of preparation method upper mold personification body natural teeth, therefore there is good biocompatibility, the film has good mechanical property, bacteria resistance and is suitable for controllable degradation rate simultaneously, and raw material is cheap and easy to get, can be widely used in oral cavity restoration field.
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