| abstract |
The invention discloses a method for synthesizing difluoroalkyl substituted pyridone or pyrone under simple conditions. Specifically, starting from simple pyridones, pyrones, and halogenated difluoroalkyl compounds (chloro, bromo, iodo), under light conditions, complexes with iridium or ruthenium as the core act as catalysts , A method for obtaining various difluoroalkyl-substituted pyridones or pyrones in high yields. The method uses simple and easy-to-obtain pyridones and pyrones and halogenated difluoroalkyl compounds (chloro, bromo, iodo) as raw materials, and has the advantages of less catalyst consumption, wide application range of substrates, easy operation and fast reaction. High efficiency and other advantages. The obtained structures are some important fluorine-containing building blocks at present, and have great application prospects in the field of biomedicine. |