abstract |
The invention relates to an o-phenylenediamine selective histone deacetylase inhibitor containing tryptophan basic skeleton. The series of compounds have the structure of general formula (I), and activity screening experiments show that the compounds of the present invention have good HDACs inhibitory activity, subtype selectivity and in vivo antitumor activity. Therefore, the present invention also relates to a pharmaceutical composition containing the compound of formula (I) and its pharmaceutical use. |