| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a43ef275ae6f6fafc66975041eb60aa7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-005 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88 |
| filingDate |
2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e1c5a6b1cf1a1049842714ba0d9e83a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_280545c082c24724c04947c4b9131262
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f27eaa4e755f41c205fcc980a3a73b3 |
| publicationDate |
2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-105658800-A |
| titleOfInvention |
CNS delivery of mRNA and its uses |
| abstract |
The present invention provides, among other things, methods and compositions for the efficient delivery of messenger RNA (mRNA) to the central nervous system (CNS). In particular, the present invention provides methods and compositions for intrathecally administering to a subject in need of delivery a composition comprising mRNA encoding a protein encapsulated within liposomes such that administration of the composition results in mRNA expression in the brain and and/or intracellular delivery in neurons in the spinal cord. The invention is particularly useful in the treatment of CNS diseases, disorders or conditions such as spinal muscular atrophy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114306369-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110741089-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109312313-A |
| priorityDate |
2013-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |