http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105646911-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L89-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08L79-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08K5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08J3-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2014-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105646911-B |
| titleOfInvention | A kind of liver target drug-carrying microballoon and its preparation method and application of pH and reduction responsiveness |
| abstract | Has the function of liver active targeting and with pH and the reduction microballoon of stimulating responsive, preparation method and purposes in medicine the present invention relates to a kind of.It is characterized in that: (1) vehicle group become galactose modified gelatin-poly- (beta-amino ester), microballoon contains linear poly- (the beta-amino ester) of disulfide bond using galactose modified gelatin, end group as secondary amine for monomer, using dialdehyde as crosslinking agent, prepared through emulsion-crosslinking method；(2) drug bearing microsphere has the constituent of antineoplastic and galactose modified gelatin-poly- (beta-amino ester), it is using doxorubicin hydrochloride as antineoplastic model drug, it is dispersed in monomer galactose modified gelatin and linear poly- (beta-amino ester), after crosslinking agent is added, two kinds of monomers crosslink reaction and are formed by microballoon；(3) microballoon prepared by has good evident characteristics to liver cell, has good pH and also primary stimuli release performance to model drug, can further develop to treat the novel targeted preparation of liver cancer. |
| priorityDate | 2014-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.