http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105646497-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2016-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105646497-B |
| titleOfInvention | Pyrrolo-triazine ketone derivatives |
| abstract | The invention belongs to field of medicine and chemical technology, particularly to pyrrolo-triazine ketone derivatives and they be used for the purposes of drug.Specifically, compound of the present invention has the purposes for inhibiting poly- (ADP- ribose) polymerase activity, also referred to as poly- (ADP- ribose) synzyme of the enzyme and poly- ADP- ribosyltransferase, commonly referred to as PARP.The compounds of this invention has the feature that Formula (1) compound, X can be NR X Or CR X R Y ；If X is NR X , then n is 1 or 2, if X is CR X R Y , then n is 1；R X It can be selected from H, it can substituted C 1‑20 Alkyl, C 5‑20 Aryl, C 3‑20 Heterocycle, amide groups, thioamides base, ester, acyl group and sulfonyl；R Y It is derived from H, hydroxyl, amino etc.；Or R X And R Y Spiral shell-C can be constituted together 3‑7 Cyclic hydrocarbon radical or heterocycle；R 2 And R 3 All it is H, or works as X=CR X R Y When, R 2 , R 3 , R X And R Y Carbon atom connected to them may be constructed together can substituted thick and aromatic rings；R 1 Selected from H or halogen；R 4 Selected from H or halogen. |
| priorityDate | 2016-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 253.