http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105646490-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e96496a9949403e2af2ca913e65bfec |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbf908d133875556ae381dd26b49b250 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4109bf8714f0e70347bea5d6b66fce0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0688f5e91a413150dd84f760b6f86846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_864a89713f890a505475751f9acac271 |
| publicationDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105646490-A |
| titleOfInvention | Indole[1,2-a]pyrimidin[4,5-b]quinoline-7,13-dione compounds, preparation method and pharmaceutical use thereof |
| abstract | Indole[1,2-a]pyrimidin[4,5-b]quinoline-7,13-dione compounds have a structural formula as shown in Formula I: The preparation method is: the compound shown in the structural formula II and the compound shown in the structural formula III are reacted for 0.5 to 10 hours according to the amount ratio of substances of 1:1 to 10, and the compound of the structural formula I is obtained, and R is an oxygen atom, that is, indole [ 2,1-b]pyrimidine[4,5-b]quinoline-7,13-dione structure; indole[2,1-b]pyrimidine[4,5-b]quinoline-7,13- Diketone and hydroxylamine hydrochloride or hydrazine hydrate are raw materials, and the amount ratio of substances is, compound I: hydroxylamine hydrochloride or hydrazine hydrate is according to the ratio of 1:1～10, reacts for 1～5h, obtains the compound of structural formula I after drying, R 1 It is NOH or NNH 2 ; it is used in antitumor and antibacterial combination drugs; the raw materials are cheap and easy to obtain, the yield is high, and the operation is simple; it is used for treating tumors and sterilizing bacteria. |
| priorityDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.