http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105646398-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 |
| filingDate | 2014-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105646398-B |
| titleOfInvention | Preparation method of N-((1R,4R)-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)acetamide |
| abstract | The invention discloses a preparation method of N-((1R,4R)-4-(4-(cyclopropylmethyl)piperazin-1-yl)cyclohexyl)acetamide, comprising the following steps: (1) The compound shown in the structural formula (2) and the compound shown in the formula (3) are reacted in the presence of the catalyst tetraisopropyl titanate in a solvent; (2) then adding an alcoholic solvent and a reducing agent, and reacting at room temperature (time B), then collect described N-((1R,4R)-4-(4-(cyclopropylmethyl) piperazin-1-yl) cyclohexyl) acetamide from the reaction product; the present invention It is a "one-pot" reaction, the product is the target product 4, the yield is high, and the reaction is controllable. A large number of experiments have proved that only when tetraisopropyl titanate/alcohol/reducing agent exist at the same time to carry out the "one pot" reaction, can the product 4 be obtained in high yield; the advantages of the present invention are: the raw materials are easy to obtain, the conditions are mild, The post-treatment is simple, the target product can be obtained in high yield, and is suitable for large-scale industrial production. |
| priorityDate | 2014-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.