http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105646371-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 |
| filingDate | 2016-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105646371-B |
| titleOfInvention | The 2,4- diaryl-amine yl pyrimidines analog derivative of the segment containing hydroxamic acid and preparation and application |
| abstract | The present invention provides 2 of the segment containing hydroxamic acid as shown in formula I and formula II; 4- diaryl-amine yl pyrimidines analog derivative; mainly with 2, the 4- diaryl-amine yl pyrimidines containing carboxy fragment for parent nucleus, target compound is obtained by the condensation of one step of azanol and relevant modification protected to THP.Experiments have shown that; in cellular level pair tumour cell relevant to EGFR tyrosine kinase activity (human lung adenocarcinoma cell line H1975 drug resistant to Gefitinib, the people's epidermis cancer cell line A431 for being overexpressed EGFR) and to tumour cells such as human cervical carcinoma cell lines Hela relevant with HDAC acetylation of histone enzymatic activity, human mouth epidermoid carcinoma cell strain KB, the early young grain acute leukemia cells strain HL60 of people, HepG2 cell lines, human colon cancer cell strain SW620; with significant inhibited proliferation, corresponding antitumor cell drug can be prepared.General structure is as follows: |
| priorityDate | 2016-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 104.