| abstract |
The invention discloses a preparation method of sulfophenylpyrazolone. The method uses compound (I) as a raw material, in the presence of a base, undergoes a substitution reaction with compound (II), and then oxidizes with an oxidant to prepare compound (III), and compound (III) is esterified to obtain compound (IV), compound ( IV) Obtain compound (VI) through thiolation, compound (VI) is further oxidized and hydrolyzed (or hydrolyzed, oxidized) to obtain compound (VII), compound (VII) is subjected to acid chlorination, and the obtained acid chloride (VIII) and 1 , 3-dimethyl-5-hydroxypyrazole undergoes an esterification reaction to obtain compound (IX), and finally compound (IX) is rearranged to obtain compound (X). The beneficial effects of the invention are mainly reflected in that the raw materials are cheap and easy to obtain, the reaction conversion rate is high, the three wastes are less, and the industrial production is beneficial. |