http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105646273-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2014-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105646273-B |
| titleOfInvention | A kind of synthetic method of ubenimex |
| abstract | The invention belongs to pharmaceutical formulating art, it is proposed that a kind of brand-new ubenimex preparation method.Described preparation method is included first by initiation material (2S; 3R) amino on the phenylbutyric acid (abbreviation AHPA) of 3 amino, 2 hydroxyl 4 is protected to form Boc protection with di-tert-butyl dicarbonate; it is condensed again with the L leucines tert-butyl ester, finally sloughs protection group in the organic solution of hydrogen chloride and obtain ubenimex.The reagent that the synthetic route that the present invention uses uses is common agents, existing industrialized production and cheap；Reaction dissolvent is usual vehicle, and toxicity is low, and environmental pollution is few；The mild condition of each step reaction, it is easy to operate, it is not necessary to special equipment, to be appropriate for industrialized production.Obtained product purity is up to more than 99.5%. |
| priorityDate | 2014-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 570.