abstract |
The present invention relates to amide derivatives and its officinal salt, its preparation method and its application in medicine.Specifically, the present invention relates to amide derivatives shown in a kind of logical formula (I), its preparation method and pharmaceutical composition containing the derivative, as well as therapeutic agent, purposes and its purposes in treatment and/or prevention of inflammation and/or pains and other diseases or the medicine of illness is prepared especially as Microsomal prostaglandin E synthetase 1s (mPGES 1) inhibitor, each substituent in its formula of (I) it is defined as the description. |