http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105622524-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105622524-B |
| titleOfInvention | Pleuromutilin analog derivative and its application |
| abstract | The present invention discloses a kind of new pleuromulins new derivative, and it has the pyrimidine heterocyclic side chain that amino substitutes, and structural formula is： Wherein, R is Or R 1 And R 2 It is independently each H or C1 C4 straight chained alkyl；M is 0,1,2 or 3；N is 1,2 or 3；X is C, N or O；R 3 For H, OH or NH 2 .The pleuromutilin analog derivative of the present invention is in vivo and in vitro to the staphylococcus aureus of multiple drug-resistant bacteria such as methicillin-resistant, and common pathogenic bacteria such as staphylococcus aureus, hay bacillus and Escherichia coli have significant inhibitory action in clinic, the bacteriostatic activity of partial derivatives is better than safe second rhzomorph, it is even suitable with valnemulin, there is potential medical value. |
| priorityDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.