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filingDate 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8a277f34fd798e019554d01f11365be
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publicationDate 2016-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-105617463-A
titleOfInvention Preparation method of polyactic acid composite funnel spider silk protein modified calcium polyphosphate bio-bone scaffold
abstract The invention discloses a preparation method of a polyactic acid composite funnel spider silk protein modified calcium polyphosphate bio-bone scaffold and belongs to the technical field of biology. The preparation method includes: collecting spider silk; soaking and drying the spider silk; mixing the spider silk with a formic acid solution, and heating through water bath; performing dialysis and centrifugal treatment to obtain high-purity spider silk protein; mixing and concentrating with substances like polyactic acid, adding into calcium polyphosphate, performing composite modification to obtain the bio-bone scaffold. The preparation method has the advantages that the preparation method is simple, the bio-bone scaffold obtained by the method is high in modulus of elasticity, less prone to deformation, long in stress time and high in tissue compatibility; the bio-bone scaffold is higher than other products in degradation rate by higher than 12%, low in brittleness and capable of effectively accelerating bone healing.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107050528-B
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