http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105601596-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-80 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-66 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105601596-B |
| titleOfInvention | Suppress compound of angiogenic activity and its preparation method and application |
| abstract | A kind of compound for suppressing angiogenesis and preparation method thereof, it comprises the following steps：Seed culture fluid is accessed into fermentation medium, in 25 30 DEG C of 72 96h of fermentation of room temperature, fermentation culture medium is soaked with methanol and extracted, zymotic fluid macroporous resin adsorption, then using ethanol elution, medicinal extract is obtained after concentration.Medicinal extract is separated using silica gel and gel column chromatography spectrum, is eluted with petrol ether/ethyl acetate and petroleum ether/chloroform/methanol current system, obtains 1 oxygen 2（2‑（2 hydroxyl isopropanols）2,3 dihydroxy benzofurans) 2 methyl formates 3（4 hydroxyl phenols）The dihydrofuran of 4 hydroxyl, 5 carbonyl 2,5.In 100 μ g/mL, blood vessel number is 14.60 ± 3.71 between body, and inhibiting rate is 43.4%；In 10 μ g/mL, blood vessel number is 19.20 ± 2.58 between body, and inhibiting rate is 25.6%；In 1 μ g/mL, blood vessel number is 22.80 ± 1.79 between body, and inhibiting rate is 11.6%, with significant difference.Compound, which has, significantly inhibits angiogenic activity, with the prospect prepared for antineoplastic. |
| priorityDate | 2015-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.