| abstract |
The invention discloses a 2-aminopyrimidine compound and its pharmaceutical composition and application. The structure of the 2-aminopyrimidine compound is shown in I. In the formula, R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, Z, W, As defined in the description and claims, this type of compound can effectively inhibit the growth of a variety of tumor cells, and has an inhibitory effect on EGFR and IGF1R proteases, can be used to prepare anti-tumor drugs, and can overcome the existing drug Gefid Drug resistance induced by tinib, erlotinib, etc. is selective for tumors, especially wild-type non-small cell lung cancer, and has good pharmacokinetic properties. . |