http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105601534-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80fdaa0d94f29478467816f48d47639e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C245-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C245-08 |
| filingDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0be20f0f2cd2cfe19a93a631f8c6ee8b |
| publicationDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105601534-A |
| titleOfInvention | Synthetic method for oxyphenbutazone drug intermediate-4-hydroxyazobenzene |
| abstract | The invention discloses a synthetic method for an oxyphenbutazone drug intermediate-4-hydroxyazobenzene. The method comprises the following steps: (i) adding 300ml of a sulfuric acid solution with a certain concentration into a reaction container equipped with a stirrer, a temperature meter and a drop funnel, controlling the stirring speed to be 100-200rpm, slowly adding 1.2mol of phenylamine, after phenylamine is completely dissolved, cooling the solution to 6-9 DEG C, dropwise adding 1.1mol of potassium bisulfite, performing dissolution in 200-230ml of water to prepare a solution, testing a reaction termination point by using potassium iodide test paper, and generating diazonium salt (3); and (ii) adding 2-2.3L of a potassium carbonate solution with a certain concentration and 1.2mol of phenol into the other container to prepare a potassium phenate solution, slowly adding a diazotization solution obtained in the step (i) at the stirring speed of 100-160rpm, controlling the temperature of the solution to be 16-20 DEG C, after the addition is finished, continuing to react for 30-40 minutes, adding an adjusting solution for maintaining the pH value of the solution to be 8-9, then adding an oxalic acid solution for reducing the pH value to be 2-3, keeping the reaction for 40-50 minutes, performing suction filtration, adding a washing solution, and performing dewatering with a dewatering agent to obtain 4-hydroxyazobenzene. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113105357-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113105357-B |
| priorityDate | 2015-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.