http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105597098-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2015-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-105597098-B |
| titleOfInvention | A kind of bonded gold nanorods compound of Herceptin, preparation method and the application in HER2 positive breast cancer diagnosis and treatment |
| abstract | The invention discloses a kind of bonded gold nanorods compound of Herceptin, preparation method and the applications in HER2 positive breast cancer diagnosis and treatment.The present invention solves the disadvantage that targeting gold nanoparticle photothermal conversion efficiency controllability difference and cannot position.The described method includes: longitudinal absorption peak is 650-850nm firstly, preparing the gold nanorods with certain draw ratio, the best optical wavelength for penetrating tissue can be met；Then, cysteine is connect with porphyrin fluorescent molecule, then pass through the effect of Au-S key, gold nanorods and cysteine-porphyrin complex key are connected, the method being chemically crosslinked finally by glutaraldehyde, gold nanorods-cysteine-porphyrin complex and drug Herceptin key are connected, the bonded gold nanorods compound of obtained Herceptin can pass through fluorescence display neoplasm in situ or micrometastatic disease, utilize the distinctive photo-thermal feature of gold nanorods, targeting photo-thermal therapy is carried out to the tumor focus detected, can effectively solve the problems, such as tumor drug resistance. |
| priorityDate | 2015-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.