| abstract |
The present invention relates to containing [2-(6-amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir Sopsy Fumarate, ) and (2R,5S,cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidine- Therapeutic combination of 2-keto (emtricitabine, Emtriva TM , (-)-cis FTC) and its physiologically functional derivatives. The combination is useful in the treatment of HIV infection, including infection by mutant HIV strains resistant to nucleoside and/or non-nucleoside inhibitors. The present invention also relates to pharmaceutical compositions and preparations containing said combination of tenofovir disoproxil fumarate and emtricitabine, and physiologically functional derivatives thereof, and treatments using such compositions and preparations. method. |